Contents: Preface. 1. Bioinformatics : introduction, databases and tools/R. Aparna. 2. Key terms in bioinformatics/R. Aparna. 3. Comparative analysis of bioinformatics tools/Kakollu, Karuna Sree and P.P. Mathur. 4. Application of reusability in bioinformatics tools/Kakollu, Karuna Sree and P.P. Mathur. 5. Drug discovery/R. Aparna. 6. Drug designing/Shyam S. Mandal. 7. Rational approach to drug designing/R. Aparna. 8. Molecular docking in drug designing/R. Aparna. 9. Structural analysis of the P53 Tumour-suppressor protein and their gene sequencing regulations/M. Sarumathi and R. Perumal Samy. 10. SiRNA and RNAi/R. Aparna. 11. Rhizoctonia : a database approach - I/S. Senthil Kumar, S. John Britto and N. Vinotha. 12. Rhizoctonia : a similarity approach/S. Senthil Kumar, S. John Britto and N. Vinotha. 13. Rhizoctonia : a database approach - II/S. Senthil Kumar, S. John Britto and N. Vinotha. 14. Study of putative homeodomain proteins in a few pathogenic species of Eubacteriae/Kakollu, Karuna Sree, S. Ramakumar, P.P. Mathur and V. Amouda. 15. Drug discovery and design/Y. Jayaprakash Rao.
"Bioinformatics is a computer based discipline which deals with the acquisition, storage, management, access and processing of data of molecular biosciences, and started with the networking of computers and accumulation of data on genes and proteins in biotechnology. It has achieved significant role with the availability of new DNA sequencing protocols and the presence of high memory desktop computers that help in storing and analyzing the data sequences. Today, it is paramount importance to whole world, in general, but particular for developing and under developed countries, because of the vast potential by genomic technologies in elaborating the process of drug development. Diagnosing and curing diseases have always been and will continue to be an art. The reason probably will living organism, in general, and humans in particular, are regarded as complex networks of molecular interactions that fuel the processes of life. This "molecular circuitry" has intended modes of operation that correspond to diseased states. In molecular medicine, the goal of diagnosing a disease is to identify its molecular basis, i.e., to answer the question what goes wrong in the molecular circuitry. The goal of therapy is to guide the biochemical circuitry back to healthy state. The molecular basis of life is formed by complex bio-chemical processes that constantly produce and recycle molecules and do so in highly coordinated and balanced fashion. The molecular basis of a disease lies in modifications of the action of these biochemical pathways."