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A Pharmacology Primer : Theory, Applications, and Methods

Terry P. Kenalin, Academic Press, 2011, pbk, Third edition, xx, 406 p, figs, tables, ISBN : 9380931524, $0.00 (Includes free airmail shipping)

A Pharmacology Primer : Theory, Applications, and MethodsContents: Preface. 1. What is pharmacology? 2. How different tissues process drug response. 3. Drug-receptor theory. 4. Pharmacological assay formats: binding. 5. Agonists: the measurement of affinity and efficacy in functional assays. 6. Orthosteric drug antagonism. 7. Allosteric drug antagonism. 8. The process of drug discovery. 9. Pharmacokinetics. 10. Target - and system-based strategies for drug discovery. 11. Hit to drug: lead optimization. 12. Statistics and experimental design. 13. Selected pharmacological methods. 14. Exercises in pharmacodynamics and pharmacokinetics. Appendices. Glossary of pharmacological terms. Index.

From the preface: This edition incorporates a new trend in drug discovery, namely the consideration of pharmacokinetics and ADME properties of drugs (absorption, distribution, metabolism, excretion) early in the process. As prospective new drugs are tested in more complex systems (with concomitantly more complex dependent variable values), the trend in screening is to test fewer compounds of higher (druglike) quality. Finally, this edition also hopefully fills a previous void whereby the ideas and concepts discussed can be applied to actual problems in pharmacological drug discovery in the form of questions with accompanying answers. The expanded version now spans pharmacology from consideration of the independent variable (drug concentration in the form of pharmacokinetics) to the dependent variable (system-independent measurement of drug activity). As with previous editions, the emphasis of this book is still on the chemist-biologist interface with special reference to the use of pharmacology by non-pharmacologists.
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