Contents: Preface. 1. Introduction to bioinformatics. 2. History of genomics. 3. Molecular evolution of genes. 4. Computational biology. 5. Physical aspects of bioinformatics. 6. Genomic mapping. 7. Protein sequence alignment. 8. Protein structure modelling. 9. Gene prediction. 10. Microarray analysis. 11. Protein data bank. 12. Applications of neural networks. 13. Large-scale genome analysis. 14. Tasks in bioinformatics. 15. Future of bioinformatics. Bibliography. Index.
"Bioinformatics is the development and use of computational and mathematical methods for acquiring, storing, analysing and interpreting biological data to solve biological questions. Today's biological research generates a huge quantity of data. This is growing exponentially with a shift in emphasis from individual biomolecules, to analysis of how they interact in complex networks which control the developmental and physiological processes of whole biological systems, and research into how this relates to human health. This transition has increased the importance of bioinformatics and raises key challenges which make it imperative that computer scientists work closely with biologists to refine existing bioinformatics tools and develop new ones.
This book describes the fundamental aspects of bioinformatics. It starts with a brief overview of the essential biological basics, followed by a review of publicly available bioinformatics databases and their importance. Sequence analysis, pairwise alignment and database searching are discussed in detail. Some of the existing open source tools for genomics and proteomics, applications to visualise biological information and the challenges offered by biology to computer scientists, etc., are also discussed. This book will serve as a good introduction to the growing fields of bioinformatics and computational biology. It is targeted to people without a significant background in biology, who intend to get a brief overview of bioinformatics." (jacket)