Contents: Foreword. Preface. 1. Good clinical practices/S.D. Seth, Rahmat Bano and N.K. Ganguly. 2. Role of Ethics Committee in clinical research/Urmila Thatte. 3. Bioavailability and bioequivalence studies in drug development/Avijit Hazra. 4. Overview of adverse drug reactions and their monitoring/Avijit Hazra and Santanu Kumar Tripathi. 5. Idiosyncratic drug reactions : revisited/Suparna Chatterjee, Dipankar Bhattacharya and S.K. Bandopadhyay. 6. Promoting rational use of drugs through Drugs and Therapeutics Committees/Usha Gupta. 7. Drugs and Therapeutics Committees: from a pharmacist's perspective/S.D. Rajendran. 8. Evaluation of drug safety/Jaideep Bhaduri. 9. Good laboratory practices: an overview/Prakash V. Diwan. 10. Vitamins and its genomic stability in humans: redefine the RDA/Nirupama Pandey, Balram Ghosh, Sudeb Mandal and Malay Chatterjee. 11. Involvement of renin-angiotensin system in the pathogenesis of cardiovascular disease/Melissa R. Dent, Tushi Singal, Paramjit S. Tappia, Suresh K. Gupta and Naranjan S. Dhalla. 12. Pharmacological basis of the action of antiarrhythmic drugs/Onkar N. Tripathi and Naranjan S. Dhalla. 13. Experimental models of atherosclerosis for the development of therapeutic interventions/Harjot K. Saini, Yan-Jun Xu, Sukhinder K. Cheema, Amarjit S. Arneja and Naranjan S. Dhalla. 14. Characteristics and mechanisms of cardioprotection due to Ischemic preconditioning/Samarjit Das, Harjot K. Saini, Jingwei Wang, Xiaobing Guo and Naranjan S. Dhalla. 15. Pharmacological treatment of resistance vessel remodeling in hypertension/Michael J. Mulvany. 16. Possible implication of Rho-kinase in Vascular endothelial dysfunction/Dhvanit I. Shah and Manjeet Singh. 17. Drug usage during percutaneous coronary interventions in patients with acute coronary syndrome and ventricular dysfunction/Ramesh K. Goyal, Kanan Mehta, Purvi S. Gandhi, Milan C. Chag, Keyur Parikh, Srinivas Mallya and Anil Jain. 18. Abdominal obesity, low-degree inflammation and cardiovascular diseases in developing countries/Patricio Lopez-Jaramillo and Patricia Pradilla S. Lina. 19. Mechanism of sensory transduction in cardiopulmonary receptors/K. Ravi. 20. Interaction between aspirin and ACE inhibitors/K. Dubey, R. Bajaj and K.K. Pillai. 21. Targeting molecular pathways in stroke/Shyam S. Sharma and Ravinder K. Kaundal. 22. Neutrophil nitric oxide synthase : functional, biochemical and molecular perspectives/Rashmi Saini, Madhumita Chatterjee and Madhu Dikshit. 23. Nitric oxide and the central nervous system: perspectives and trends/Arunabha Ray and Kavita Gulati. 24. Application of bioinformatics in drug designing in antimalarial drug targets/Subhash Choudhary, Ananta Paine and Indira Ghosh. 25. Rational therapy of tuberculosis using fixed-dose combination products : bioavailability and stability issues/Saranjit Singh. 26. Rational antibiotic therapy in hospital acquired pneumonia/S.K. Chhabra. 27. Tumor cell surface Integrins and Metallomatrix Proteinases (MMPs) cross-talk: a potential area for developing anti-metastatic drugs/Aparna Mitra, Jayati Chakrabarti, Aniruddha Banerji and Amitava Chatterjee. 28. Free radicals and drug toxicity: focus on theophylline/Kavita Gulati, Arunabha Ray, Rishi Pal and V.K. Vijayan. 29. Search for a safe, effective and specific treatment for chronic arsenic poisoning/SJS Flora and Govinder Flora. 30. Pesticide-induced immunomodulation: influence of various factors/B.D. Banerjee, Ayanabha Chakraborti, Sanvidhan G. Suke, Rafat S. Ahmed, A.K. Tripathi and Arunabha Ray. 31. Prakriti to genome: a journey from Vedic to genomic era/C.K. Katiyar and Yogita Rani. 32. Clinical trials on herbal drugs: limitations and way forward/C.K. Katiyar. 33. Rational approach for the safe use of herbal medicines/P. Sen and Madhumita Banerji. 34. Ulcer protective effect of aqueous extract of neem (Azadirachta indica) leaf/R.K. Goel. M. Dorababu, G. Bhawani, M. Mohankumar. Index.
"Pharmacology is a rapidly progressing area of biomedical research, with new developments surfacing at regular intervals, constantly revolutionizing drug therapy for disease states. The interaction of this discipline with other biomedical sciences has opened up new vistas and opportunities in drug design and development. Basic and clinical concepts in the mechanism and use of drugs are carefully integrated into hypotheses, which are aimed at the maintenance of a critical balance between health and diseases.
Current Trends in Pharmacology is a comprehensive collection of topics highly significant in the current health scenario. The book comprises a combination of articles in clinical and experimental pharmacology and toxicology from the view point of both basic and clinical scientists. It also details recent developments in the basic aspects of drug action in some very relevant disease states like hypertension, atherosclerosis, arrhythmia, stroke, tuberculosis, hospital acquired pneumonia, and cancer. It also highlights the applied issues relating to rational use of drugs. The contributing authors are leading experts in their respective fields and have presented the topics in a lucid and comprehensive manner.
The book will be of interest to students, scientists and health professionals in the area of pharmacology, toxicology and allied biomedical sciences."
