Subjects

Applied Biocatalysis in Pharmaceuticals

Edited by Vivek Kothari, Biotech Books, 2007, viii, 276 p, figs, tables, ISBN : 8176221708, $36.00 (Includes free airmail shipping)

Contents:  Preface. 1. Introduction. 2. Synthesis of Chiral intermediates. 3. Synthesis of Amino alcohols. 4. Enzymatic synthesis of Amplicillin. 5. Synthesis of Chiral amines with w-transaminase. 6. Synthesis of Chiral long chain diamines and tetramines. 7. Applications for oxidoreductases. 8. Non-aqueous biocatalysis. 9. Eukaryotes for industrial biocatalysis. 10. Biopolymers for biocatalysis. 11. Use of enantiopure Naphthalene Dihydrodiols. 12. Multidrug-resistant mycobacterium tuberculosis. 13. Flavin biochemistry. Bibliography. Index.

"Bioacatalysis has increasingly become the technology of choice to introduce chirality in fine-chemical processes. Biocatalysis sculpts chemical precursors into the precise molecular shapes that are the heart of many pharmaceuticals. In reviewing how biocatalysis can be applied to improve Chiral synthesis for pharmaceutical it becomes clear that there will be many opportunities using a simple enzyme system by that many of the more useful applications will require the whole cell because of the requirement for cofactors.

In the ever more global commercial arena, biocatalysts becomes ever more central to the competitiveness of individuals products, companies, industries, and countries. The use of biocatalysis often leads to less complex, syntheses, lower production costs, and more sustainable production processes.

Written for practitioners and students of chemistry, biology and bioengineering, this book provides a comprehensive review of the applications of biocatalysis in the pharmaceutical industry." (jacket)

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