Molecular Interactions
Contents: 1. Theory of atomic and molecular orbitals. 2. Molecular orbital theory. 3. Linear combination of atomic orbitals and valence bond theory. 4. Resonance structures. 5. SIGMA bonds and pi bonds. 6. Electrovalent bond. 7. Covalent bond. 8. Van Der waals force and metallic bond. 9. Molecular geometry and shape of orbitals. 10. Hybridization of atomic orbitals and VSEPR theory. 11. Protein folding. 12. Protein Denaturation. 13. Molecular chaperones. 14. Molecular forces in relation to protein structure. 15. Helices and turns. 16. Protein protein interactions. 17. Protein DNA interaction. 18. DNA Drug interactions, Metalloproteins and protein ligand interactions. 19. Interaction of protein with lipids and carbohydrates. 20. PI…PI Interaction and C-H…PI interaction. 21. Ultraviolet-visible spectroscopy. 22. Infrared spectroscopy. 23. Nuclear magnetic resonance spectroscopy. 24. Circular dichroism spectroscopy.
Molecular interactions are forces of attraction or repulsion which act between neighboring particles (atoms, molecules or ions). They are weak compared to the intramolecular forces, the forces which keep a molecule together. The investigation of intermolecular forces starts from macroscopic observations which point out the existence and action of forces at molecular level.
Molecular interactions are of key importance to many chemical and biological processes such as protein folding and function, peptide aggregation, enzymatic reactions, or the stabilization of reactive species, to name but a few, Intermolecular interactions between solvent (water in most cases of biological relevance) and solute molecules determine the aggregation of proteins into fibrils, enzyme catalysis, and other biological processes.
Written to describe state of the art computational tools and the construction of new models of complex systems to investigate molecular interactions of proteins, organic molecules, solvents, co-solvents and lipid bilayers. Molecular interactions are to explore the properties, reactivity, and applications of complex systems consisting of a large number of interacting molecules.
