Transgenic Animals in Agriculture

Contents: Preface. 1. Transgenic farm animals/C.A. Pinkert and J.D. Murray. 2. Development of genetic tools for transgenic animals/P.B. Hackett, Z. Izsvak, Z. Ivics and L. Caldovic. 3. One gene is not enough: transgene detection, expression and control/K.D. Wells and R.J. Wall. 4. Embryonic stem cells in agricultural species/G.B. Anderson. 5. Nuclear transfer in the production of transgenic farm animals/I. Wilmut, E. Schnieke, J. Mc Whir, A.J. Kind, A. Colman and K.H.S. Campbell. 6. Embryonic stem cell chimeras and somatic cell nuclear transplantation for production of transgenic cattle/J.M. Robl, J.B. Cibelli, P.G. Golueke, J.J. Kane, C. Blackwell, J. Jerry, E.S. Dickenson, F.A. Ponce de Leon and S.L. Stice. 7. Status of sperm-mediated delivery methods for gene transfer/E.J. Squires. 8. Understanding the origin of Avian primordial germ cells: implications for germ cell culture and transgenesis in poultry/J.N. Petitte, S. D'Costa and L. Karagenc. 9. Generation of transgenic poultry by transfection of primordial germ cells/E.A. Wong, A.L. Wentworth, B.C. Wentworth, J.A. Proudman and M.E. El Halawani. 10. Expression of insulin-like growth factor-I in skeletal muscle of transgenic swine/V.G. Pursel, R.J. Wall, A.D. Mitchell, T.H. Elasser, M.B. Solomon, M.E. Coleman, F. DeMayo and R.J. Schwartz. 11. Production and analysis of transgenic pigs containing a metallothionein porcine growth hormone gene construct/M.B. Nottle, H. Nagashima, P.J. Verma, Z.T. Du, C.G. Grupen, S.M. McIlfatrick, R.J. Ashman, M.P. Harding, C. Giannakis, P.L. Wigley, I.G. Lyons, D.T. Harrison, B.G. Luxford, R.G. Campbell, R.J. Crawford and A.J. Robins. 12. The utilization of bacterial genes to modify domestic animal biochemistry/K.A. Ward, Z. Leish, A.G. Brownlee, J. Bonsing, C.D. Nancarrow and B.W. Brown. 13. Production of transgenic cattle expressing a recombinant protein in milk/W.H. Eyestone. 14. Changing the composition and properties of milk J.D. Murray and E.A. Maga. 15. Comparison of traditional breeding and transgenesis in farmed fish with implications for growth enhancement and fitness/R.A. Dunham and R.H. Devlin. 16. Direct and correlated responses to short-term selection of 8-week body weight in lines of transgenic (oMt1a-oGH) mice/F. Siewerdt, E.J. Eisen and J.D. Murray. 17. Ethics, animal welfare and transgenic farm animals/J.A. Mench. 18. The future of transgenic farm animals/G.E. Seidel. Index.

"In the past decade, a number of advances have been made in genetic engineering as applied to farmed animals. This book has been developed from invited presentations at a conference held in California in August 1997 to address this issue. It is written by representatives form the leading laboratories involved in attempts to improve agriculturally important mammals, poultry and fish. Current knowledge, methodology, technical improvements and successes in the applications of transgenic technology to a range of animals which are important in agriculture are brought together for the first time under one cover. The book is essential reading for research workers in animal genetics, breeding and biotechnology."